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AttributesValues
rdf:type
rdfs:label
  • Sapacitabine
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Sapacitabine
UMLS_CUI
  • C0764827
CAS_Registry
  • 151823-14-2
FDA_UNII_Code
  • W335P73C3L
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 513165
PDQ_Closed_Trial_Search_ID
  • 513165
Chemical_Formula
  • C26H42N4O5
Legacy_Concept_Name
  • Sapacitabine
FULL_SYN
  • SapacitabinePTNCI
  • CS-682CNNCI
  • CYC682CNNCI
  • N-[1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl]-2-oxo-1,2-dihydropyrimidin-4-yl}hexadecanamideSNNCI
  • SAPACITABINEPTFDAW335P73C3L
DEFINITION
  • An orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. The unmetabolized prodrug may exhibit antineoplastic activity as well.NCI
code
  • C64541
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