| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:label
| |
| rdfs:subClassOf
| |
| Has_Salt_Form
| |
| Concept_In_Subset
| |
| Semantic_Type
| - Amino Acid, Peptide, or Protein
- Pharmacologic Substance
|
| Preferred_Name
| |
| NSC_Code
| |
| UMLS_CUI
| |
| CAS_Registry
| |
| Accepted_Therapeutic_Use_For
| - Abortion; Bladder cancer; Breast cancer; Carcinomatous; meningitis; Chorioadenoma destruens; Crohn's disease; Ectopic pregnancy; Esophageal cancer; Gestational choriocarcinoma
- Graft versus host disease-prophylaxis; Head/neck cancer; Hydatidiform mole; Leukemia; meningeal; Lymphomas; Acute Lymphoblastic Leukemia; Burkitt's; Lung cancer; Mycosis fungoides; Osteosarcoma; Psoriasis; Rheumatoid arthritis; Wegener's granulomatosis
|
| In_Clinical_Trial_For
| - Acute lymphoblastic leukemia; Breast cancer; Central Nervous System lymphoma; Chronic lymphocytic leukemia; Demyelinating Disorders; Gestational trophoblastic neoplasia; Head and Neck Cancer
- Multiple Sclerosis; Optic Neuritis; Myelitis; Neuritis; Primary central nervous system lymphoma; Soft tissue sarcoma
|
| FDA_UNII_Code
| |
| Contributing_Source
| |
| ALT_DEFINITION
| - A drug used to treat some types of cancer, rheumatoid arthritis, and severe skin conditions, such as psoriasis. Amethopterin stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite.NCI-GLOSS
|
| PDQ_Open_Trial_Search_ID
| |
| PDQ_Closed_Trial_Search_ID
| |
| Chemical_Formula
| |
| Legacy_Concept_Name
| |
| CHEBI_ID
| |
| FULL_SYN
| - METHOTREXATEPTFDAYL5FZ2Y5U1
- FarmitrexatFBNCI
- MetotrexatoSYNCI
- RheumatrexPTNCI-GLOSSCDR0000413957
- AmethopterinSYDTPNSC0000740
- MedsatrexateFBNCI
- LedertrexateFBNCI
- MethoblastinFBNCI
- AmethopterinBRNCI
- MethotrexatePTNCI
- FolexSYDTPNSC0027720
- MethotrexatumSYNCI
- MethotrexateSYNCITCGA
- MTXABNCI
- amethopterinPTNCI-GLOSSCDR0000428246
- methotrexatePTNCI-GLOSSCDR0000045393
- CL 14377SYDTPNSC0000740
- 4-Amino-10-methylfolic AcidSNNCI
- MethotrexatePTDCP05757
- Methotrexate LPFBRNCI
- FolexBRNCI
- MetexFBNCI
- 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic AcidSNNCI
- Alpha-MethopterinSYNCI
- MexateBRNCI
- TexateFBNCI
- LumexonFBNCI
- MaxtrexFBNCI
- N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic AcidSNNCI
- CL-14377CNNCI
- WR-19039CNNCI
- LantarelFBNCI
- EmtexateFBNCI
- EmthexatFBNCI
- TremetexFBNCI
- TrixilemFBNCI
- NovatrexFBNCI
- TrexeronFBNCI
- MetrotexFBNCI
- Methotrexate MethylaminopterinSYNCI
- Folex PFSBRNCI
- Mexate-AQBRNCI
- BrimexateFBNCI
- EmthexateFBNCI
- AbitrexateBRNCI
- FauldexatoFBNCI
- RheumatrexBRNCI
|
| DEFINITION
| - An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.NCI
|
| code
| |
| is someValuesFrom
of | |
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