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AttributesValues
rdf:type
rdfs:label
  • Resiquimod
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Resiquimod
UMLS_CUI
  • C0910999
CAS_Registry
  • 144875-48-9
FDA_UNII_Code
  • V3DMU7PVXF
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of some types of skin cancer. When put on the skin, resiquimod causes some immune cells to make certain chemicals that may help them kill tumor cells. It is also being studied to find out if adding it to a tumor vaccine improves the antitumor immune response. It is a type of imidazoquinoline and a type of immunomodulator.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 544217
PDQ_Closed_Trial_Search_ID
  • 544217
Chemical_Formula
  • C17H22N4O2
Legacy_Concept_Name
  • Resiquimod
CHEBI_ID
  • CHEBI:36706
FULL_SYN
  • resiquimodPTNCI-GLOSSCDR0000557354
  • ResiquimodPTDCP50685
  • R848CNNCI
  • 4-Amino-2-(ethoxymethyl)-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanolSNNCI
  • S 28463CNNCI
  • RESIQUIMODPTFDAV3DMU7PVXF
  • ResiquimodPTNCI
DEFINITION
  • An imidazoquinolinamine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes. Due to its immunostimulatory activity, this agent may potentially be useful as a vaccine adjuvant.NCI
code
  • C63958
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