About: Fenretinide Lipid Matrix     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fenretinide Lipid Matrix
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Fenretinide Lipid Matrix
UMLS_CUI
  • C1831747
ALT_DEFINITION
  • A powdered form of fenretinide that is being studied in the treatment of neuroblastoma. It may be used by the body more easily than the pill form. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 468556
PDQ_Closed_Trial_Search_ID
  • 468556
Legacy_Concept_Name
  • Fenretinide_Lipid_Matrix
FULL_SYN
  • Fenretinide Lym-X-SorbBRNCI
  • Fenretinide Lipid MatrixPTNCI
  • Fenretinide LXSBRNCI
  • fenretinide LXSPTNCI-GLOSSCDR0000471779
  • fenretinide Lym-X-SorbPTNCI-GLOSSCDR0000513058
DEFINITION
  • An orally bioavailable powder formulation of a synthetic phenylretinamide analogue of retinol with potential chemopreventive and antineoplastic activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types, including those of the colon, breast, prostate, and neuroblastoma. Independent of RAR activation, this agent also modulates gene expression that leads to ceramide-induced, caspase-independent programmed cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species (ROS). Compared to the capsule form, the powder contains a mixture of wheat flour, fats, and sugar that may contribute to the enhanced bioavailability of fenretinide.NCI
code
  • C63482
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