About: Melphalan

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Melphalan
rdfs:subClassOf	Nitrogen Mustard Compounds
Has_Salt_Form	MELPHALAN HYDROCHLORIDE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Melphalan
NSC_Code	241286 8806
UMLS_CUI	C0025241
CAS_Registry	148-82-3
Accepted_Therapeutic_Use_For	Breast cancer; neuroblastoma; palliative treatment of multiple myeloma and nonresectable epithelial ovarian carcinoma; rhabdomyosarcoma
In_Clinical_Trial_For	Breast cancer; colorectal cancer; Ewings sarcoma; hematologic cancer; leukemia; liver cancer; lymphoma; multiple myeloma; neuroblastoma; ovarian epithelial cancer; primary systemic amyloidosis
FDA_UNII_Code	Q41OR9510P
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42973
PDQ_Closed_Trial_Search_ID	42973
Chemical_Formula	C13H18Cl2N2O2
Legacy_Concept_Name	Melphalan
CHEBI_ID	CHEBI:28876
FULL_SYN	MelphalanumFBNCI 4-[bis(2-chloroethyl)amino]-L-phenylalanineSNNCI SarcoclorinSYNCI L-SarcolysinSYDTPNSC0241286 L-Phenylalanine MustardSYNCI L-sarcolysinSYNCI L-Sarcolysin Phenylalanine mustardSYNCI L-SarcolysineSYNCI L-SarcolysineSYDTPNSC0241286 L-PAMABNCI p-di(chloroethyl)amino-L-phenylalanineSNNCI MELPHALANPTFDAQ41OR9510P L-Phenylalanine mustardSYDTPNSC0241286 CB-3025CNNCI Phenylalanine nitrogen mustardSYDTPNSC0241286 WR-19813CNNCI Alanine Nitrogen MustardSYDTPNSC0008806 Phenylalanine Nitrogen MustardSYNCI SarkolysinSYDTPNSC0241286 MelphalanPTNCI melphalanPTNCI-GLOSSCDR0000045957 Phenylalanine MustardSYNCI SarkolysinFBNCI
DEFINITION	An orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. (NCI04)NCI
code	C633
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