About: Mechlorethamine Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Mechlorethamine Hydrochloride
rdfs:subClassOf	Nitrogen Mustard Compounds
Has_Free_Acid_Or_Base_Form	MECHLORETHAMINE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Mechlorethamine Hydrochloride
NSC_Code	762
UMLS_CUI	C0600266
CAS_Registry	55-86-7
Accepted_Therapeutic_Use_For	Bronchogenic carcinoma; chronic lymphocytic and myelcytic leukemia; Hodgkins dieseas, palliative; lymphosarcoma; mycosis fungoides; polycythemia vera
In_Clinical_Trial_For	Hodgkins lymphoma
FDA_UNII_Code	L0MR697HHI
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat some types of cancer and some skin conditions that may become cancer. It attaches to the cell's DNA and may kill cancer cells. Mechlorethamine hydrochloride is a type of alkylating agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43434
PDQ_Closed_Trial_Search_ID	43434
Chemical_Formula	C5H11Cl2N.HCl
Legacy_Concept_Name	Nitrogen_Mustard
CHEBI_ID	CHEBI:55368
FULL_SYN	CaryolysineSYDTPNSC0000762 CaryolysineFBNCI Bis(2-chloroethyl)methylamine HydrochlorideSNNCI Chlormethine hydrochlorideSYDTPNSC0000762 Methylchlorethamine HydrochlorideSYNCI Mustargen HydrochlorideSYNCI MECHLORETHAMINE HYDROCHLORIDEPTFDAL0MR697HHI Mustargen HClSYNCI Onco-CloraminFBNCI N-LostSYDTPNSC0000762 ErasolSYDTPNSC0000762 Methylbis(beta-chloroethyl)amine HydrochloridePTDCP03114 Mustine hydrochlorideSYDTPNSC0000762 Chlormethine HydrochlorideSYNCI Methylbis(beta-chloroethyl)amine HydrochlorideSNNCI Chlorethazine HydrochlorideSYNCI Chloromethine HydrochlorideSYNCI chlorethamine hydrochlorideSYNCI Mechlorethamine hydrochlorideSYDTPNSC0000762 Chlorethamine HClSYNCI Chloromethine HClSYNCI N-LostSYNCI ErasolFBNCI HN 2 HydrochlorideABNCI mustinePTNCI-GLOSSCDR0000476625 Mustargen hydrochlorideSYDTPNSC0000762 Mechlorethamine HydrochloridePTNCI mechlorethamine HClSYNCI CloraminFBNCI WR-147650CNNCI MustargenBRNCI ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl HydrochlorideSNNCI mechlorethamine hydrochloridePTNCI-GLOSSCDR0000046603 MustargenPTNCI-GLOSSCDR0000413950 Mustine HydrochlorideFBNCI
DEFINITION	The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties.NCI
code	C627
is someValuesFrom of	nodeID://b651036 nodeID://b651083 nodeID://b651085 nodeID://b651103 nodeID://b651117 nodeID://b651124 nodeID://b651174 nodeID://b657076 nodeID://b659555 nodeID://b662772 nodeID://b663536 nodeID://b667590 nodeID://b691035 nodeID://b691042 nodeID://b692139 nodeID://b692143 nodeID://b692147 nodeID://b692152 nodeID://b692159 nodeID://b692163 nodeID://b692165 nodeID://b715925
is Has_Salt_Form of	MECHLORETHAMINE

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