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AttributesValues
rdf:type
rdfs:label
  • Maytansine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Maytansine
NSC_Code
  • 153858
UMLS_CUI
  • C0024975
CAS_Registry
  • 35846-53-8
FDA_UNII_Code
  • 14083FR882
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39492
PDQ_Closed_Trial_Search_ID
  • 39492
Chemical_Formula
  • C34H46ClN3O10
Legacy_Concept_Name
  • Maytansine
FULL_SYN
  • Alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9, 22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dioneSYDTPNSC0153858
  • alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dioneSNNCI
  • MaysanineSYDTPNSC0153858
  • MaytansinSYDTPNSC0153858
  • MAYTANSINEPTFDA14083FR882
  • MaitansineSYDTPNSC0153858
  • MaytansineSYDTPNSC0153858
  • L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]SNNCI
  • MaysanineSYNCI
  • MaytansinSYNCI
  • L-Alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8, 23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*, 3R*,5R*,6R*,16E,18E,20S*,21R*)]-SYDTPNSC0153858
  • MaitansineSYNCI
  • MaytansinePTNCI
DEFINITION
  • An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04)NCI
code
  • C626
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