About: 14C BMS-275183     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • 14C BMS-275183
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • 14C BMS-275183
UMLS_CUI
  • C1831856
PDQ_Open_Trial_Search_ID
  • 487486
PDQ_Closed_Trial_Search_ID
  • 487486
Legacy_Concept_Name
  • _14C_BMS-275183
FULL_SYN
  • 14C BMS-275183PTNCI
  • [14C] BMS-275183SYNCI
DEFINITION
  • An orally bioavailable taxane compound, a C-4 methyl carbonate analogue of paclitaxel, labeled with radioactive carbon 14, with potential antineoplastic and radioimaging activities. BMS-275183 binds to tubulin and as a result inhibits microtubule disassembly or assembly. This leads to cell cycle arrest at the G2/M phase, thereby resulting in an inhibition of cell division and ultimately cell death. BMS-275183 may be useful for treating multi-drug resistant tumors as it does not appear to be a substrate for P-glycoprotein.NCI
code
  • C62553
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