About: Phosphorodiamidate Morpholino Oligomer AVI-4126

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About: Phosphorodiamidate Morpholino Oligomer AVI-4126 Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Phosphorodiamidate Morpholino Oligomer AVI-4126
rdfs:subClassOf	Oligonucleotides, Antisense nodeID://b643461 nodeID://b643462 nodeID://b643463
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Phosphorodiamidate Morpholino Oligomer AVI-4126
UMLS_CUI	C1450425
PDQ_Open_Trial_Search_ID	496940
PDQ_Closed_Trial_Search_ID	496940
Legacy_Concept_Name	AVI-4126
FULL_SYN	PMO AVI-4126ABNCI Phosphorodiamidate Morpholino Oligomer AVI-4126PTNCI AVI-4126ABNCI
DEFINITION	A c-Myc antisense phosphorodiamidate morpholino oligomer (PMO) with potential antineoplastic activity. Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis.NCI
code	C62518

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