About: Eltrombopag Olamine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Eltrombopag Olamine
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Eltrombopag Olamine
UMLS_CUI
  • C1880492
CAS_Registry
  • 496775-62-3
Accepted_Therapeutic_Use_For
  • Chronic Idiopathic Thrombocytopenic Purpura
FDA_UNII_Code
  • 4U07F515LG
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat chronic immune thrombocytopenic purpura (a condition in which platelets are destroyed by the immune system). It causes more platelets to be made in the bone marrow. It is also being studied in the treatment of low platelet counts caused by chemotherapy. It is a type of thrombopoietin receptor agonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 491973
PDQ_Closed_Trial_Search_ID
  • 491973
Chemical_Formula
  • C25H22N4O4.2C2H7NO
Legacy_Concept_Name
  • Eltrombopag
FULL_SYN
  • SB-497115-GRCNNCI
  • eltrombopag olaminePTNCI-GLOSSCDR0000628802
  • Eltrombopag OlaminePTNCI
  • PromactaPTNCI-GLOSSCDR0000628803
  • PromactaBRNCI
  • ELTROMBOPAG OLAMINEPTFDA4U07F515LG
DEFINITION
  • The orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.NCI
code
  • C62501
is Has_Salt_Form of
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