About: Multitargeted Tyrosine Kinase Inhibitor XL647     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Multitargeted Tyrosine Kinase Inhibitor XL647
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Multitargeted Tyrosine Kinase Inhibitor XL647
PubMedID_Primary_Reference
  • 22011666
UMLS_CUI
  • C1541356
PDQ_Open_Trial_Search_ID
  • 386183
PDQ_Closed_Trial_Search_ID
  • 386183
Legacy_Concept_Name
  • XL647
FULL_SYN
  • Multitargeted Tyrosine Kinase Inhibitor XL647PTNCI
  • KD019CNNCI
  • XL647CNNCI
DEFINITION
  • An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression.NCI
code
  • C62496
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