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AttributesValues
rdf:type
rdfs:label
  • Urelumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Urelumab
UMLS_CUI
  • C1831875
CAS_Registry
  • 934823-49-1
FDA_UNII_Code
  • 230902QLLC
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 489120
PDQ_Closed_Trial_Search_ID
  • 489120
Legacy_Concept_Name
  • Anti-CD137_Monoclonal_Antibody
FULL_SYN
  • URELUMABPTFDA230902QLLC
  • Immunoglobulin G4, Anti-(Human Receptor 4-1BB) (Human Gamma-Chain), Disulfide with Human Kappa-Chain, DimerSYNCI
  • Anti-4-1BB Monoclonal AntibodySYNCI
  • Anti-CD137 Monoclonal AntibodySYNCI
  • UrelumabPTNCI
  • BMS-663513CNNCI
DEFINITION
  • A fully human agonistic monoclonal antibody targeting the CD137 receptor with potential immunostimulatory and antineoplastic activities. Anti-CD137 monoclonal antibody specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. CD137 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family of receptors and is expressed by activated T- and B-lymphocytes and monocytes; its ligand has been found to play an important role in the regulation of immune responses.NCI
code
  • C62449
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