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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tobramycin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Tobramycin
UMLS_CUI
  • C0040341
CAS_Registry
  • 32986-56-4
FDA_UNII_Code
  • VZ8RRZ51VK
Contributing_Source
  • FDA
Chemical_Formula
  • C18H37N5O9
Legacy_Concept_Name
  • Tobramycin_Base
CHEBI_ID
  • CHEBI:28864
FULL_SYN
  • TOBRAMYCINPTFDAVZ8RRZ51VK
  • TOBRAMYCINSYDTPNSC0180514
  • TobramycinPTNCI
DEFINITION
  • An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.NCI
code
  • C62082
is Has_Free_Acid_Or_Base_Form of
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