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AttributesValues
rdf:type
rdfs:label
  • Thiethylperazine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Thiethylperazine
UMLS_CUI
  • C0039865
CAS_Registry
  • 1420-55-9
FDA_UNII_Code
  • 8ETK1WAF6R
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to prevent or reduce nausea and vomiting. It belongs to the families of drugs called antiemetics and phenothiazines.NCI-GLOSS
Chemical_Formula
  • C22H29N3S2
Legacy_Concept_Name
  • Thiethylperazine_Base
CHEBI_ID
  • CHEBI:9544
FULL_SYN
  • THIETHYLPERAZINEPTFDA8ETK1WAF6R
  • ThiethylperazinePTNCI
  • thiethylperazinePTNCI-GLOSSCDR0000467870
DEFINITION
  • A piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.NCI
code
  • C62081
is Has_Free_Acid_Or_Base_Form of
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