About: Phenoxybenzamine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Phenoxybenzamine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Hazardous or Poisonous Substance
Preferred_Name
  • Phenoxybenzamine
UMLS_CUI
  • C0031441
CAS_Registry
  • 59-96-1
FDA_UNII_Code
  • 0TTZ664R7Z
Contributing_Source
  • FDA
Chemical_Formula
  • C18H22ClNO
Legacy_Concept_Name
  • Phenoxybenzamine_Base
FULL_SYN
  • N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamineSNNCI
  • PHENOXYBENZAMINEPTFDA0TTZ664R7Z
  • PhenoxybenzaminePTNCI
DEFINITION
  • A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.NCI
code
  • C62065
is Has_Free_Acid_Or_Base_Form of
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