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AttributesValues
rdf:type
rdfs:label
  • Mexiletine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Mexiletine
UMLS_CUI
  • C0025887
CAS_Registry
  • 31828-71-4
FDA_UNII_Code
  • 1U511HHV4Z
Contributing_Source
  • FDA
Chemical_Formula
  • C11H17NO
Legacy_Concept_Name
  • Mexiletine_Base
CHEBI_ID
  • CHEBI:6916
FULL_SYN
  • MexiletinumSYNCI
  • 1-Methyl-2-(2,6-xylyloxy)ethylamineSNNCI
  • 2-Propanamine, 1-(2,6-dimethylphenoxy)-SNNCI
  • MEXILETINEPTFDA1U511HHV4Z
  • MexiletinePTNCI
DEFINITION
  • A local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system.NCI
code
  • C62047
is Has_Free_Acid_Or_Base_Form of
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