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AttributesValues
rdf:type
rdfs:label
  • Leuprolide
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Leuprolide
NSC_Code
  • 377526
UMLS_CUI
  • C0085272
CAS_Registry
  • 53714-56-0
FDA_UNII_Code
  • EFY6W0M8TG
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug used to treat symptoms of advanced prostate cancer. It is also used to treat early puberty in children and certain gynecologic conditions. It is being studied in the treatment of other conditions and types of cancer. Leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. It is a type of gonadotropin-releasing hormone analog.NCI-GLOSS
Chemical_Formula
  • C59H84N16O12
Legacy_Concept_Name
  • Leuprolide_Base
CHEBI_ID
  • CHEBI:6427
FULL_SYN
  • LeuprorelinSYNCI
  • leuprolidePTNCI-GLOSSCDR0000045274
  • LeuprolidePTDCP01409
  • 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig)SNNCI
  • 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig)SNNCI
  • LEUPROLIDEPTFDAEFY6W0M8TG
  • LeuprolideSYDTPNSC0377526
  • LeuprolidePTNCI
DEFINITION
  • A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.NCI
code
  • C62042
is Has_Free_Acid_Or_Base_Form of
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