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AttributesValues
rdf:type
rdfs:label
  • Cephalothin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Cephalothin
UMLS_CUI
  • C0007735
CAS_Registry
  • 153-61-7
FDA_UNII_Code
  • R72LW146E6
Contributing_Source
  • FDA
Chemical_Formula
  • C16H16N2O6S2
Legacy_Concept_Name
  • Cephalothin_Base
CHEBI_ID
  • CHEBI:124991
FULL_SYN
  • CephalothinPTNCI
  • CEPHALOTHINPTFDAR72LW146E6
DEFINITION
  • A semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C62021
is Has_Free_Acid_Or_Base_Form of
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