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AttributesValues
rdf:type
rdfs:label
  • Amiodarone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Amiodarone
UMLS_CUI
  • C0002598
CAS_Registry
  • 1951-25-3
FDA_UNII_Code
  • N3RQ532IUT
Contributing_Source
  • FDA
Chemical_Formula
  • C25H29I2NO3
Legacy_Concept_Name
  • Amiodarone_Base
CHEBI_ID
  • CHEBI:2663
FULL_SYN
  • AMIODARONEPTFDAN3RQ532IUT
  • AmiodaronePTNCI
DEFINITION
  • An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.NCI
code
  • C62002
is Has_Free_Acid_Or_Base_Form of
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