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AttributesValues
rdf:type
rdfs:label
  • Lovastatin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lovastatin
NSC_Code
  • 633781
UMLS_CUI
  • C0024027
CAS_Registry
  • 75330-75-5
Accepted_Therapeutic_Use_For
  • Atherosclerosis; Coronary heart disease, prevention; Hypercholesterolemia
In_Clinical_Trial_For
  • Alzheimer's disease; cerebrotendinous xanthomatosis; intermittent claudication, walking peak time;
FDA_UNII_Code
  • 9LHU78OQFD
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to lower the amount of cholesterol in the blood. It is also being studied in the prevention and treatment of some types of cancer. Lovastatin is a type of HMG-CoA reductase inhibitor (statin).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41658
PDQ_Closed_Trial_Search_ID
  • 41658
Chemical_Formula
  • C24H36O5
Legacy_Concept_Name
  • Lovastatin
CHEBI_ID
  • CHEBI:40303
FULL_SYN
  • (2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl EsterSNNCI
  • Monacolin KSYNCI
  • lovastatinPTNCI-GLOSSCDR0000549703
  • LovastatinPTDCP30571
  • MevacorSYDTPNSC0633781
  • Lovastatin SodiumSYNCI
  • MevacorPTNCI-GLOSSCDR0000584175
  • MevacorBRNCI
  • LOVASTATINPTFDA9LHU78OQFD
  • LovastatinSYDTPNSC0633781
  • MevinolinSYNCI
  • LovastatinPTNCI
DEFINITION
  • A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation.NCI
code
  • C620
is someValuesFrom of
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