About: Tiludronate Disodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tiludronate Disodium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tiludronate Disodium
UMLS_CUI
  • C0286030
CAS_Registry
  • 149845-07-8
FDA_UNII_Code
  • BH6M93CIA0
Contributing_Source
  • FDA
Chemical_Formula
  • C7H7ClO6P2S.2Na
Legacy_Concept_Name
  • Tiludronate_Disodium
FULL_SYN
  • TILUDRONATE DISODIUMPTFDABH6M93CIA0
  • SkelidBRNCI
  • Tiludronate DisodiumPTNCI
DEFINITION
  • The disodium salt form of tiludronate, a first-generation, non-nitrogenous bisphosphonate analogue of endogenous pyrophosphate. Tiludronate adsorbs to hydroxyapatite cells, and although the exact mechanism through which this bisphosphonate exerts its effect has yet to be fully elucidated, tiludronate appears to inhibit protein-tyrosine-phosphatase (PTP) in osteoclasts, thereby disrupting the cytoskeletal ring structure and suppressing the bone resorbing activity of osteoclasts. In addition, tiludronate appears to inhibit the vacuolar-type proton ATPase (V-ATPase) in osteoclasts. Altogether, this may reduce the number of osteoclasts, inhibit abnormal bone resorption and reduce bone turnover.NCI
code
  • C61973
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