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AttributesValues
rdf:type
rdfs:label
  • Streptomycin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Streptomycin
UMLS_CUI
  • C0038425
CAS_Registry
  • 57-92-1
FDA_UNII_Code
  • Y45QSO73OB
Contributing_Source
  • FDA
Chemical_Formula
  • C21H39N7O12
Legacy_Concept_Name
  • Streptomycin
CHEBI_ID
  • CHEBI:17076
FULL_SYN
  • STREPTOMYCINPTFDAY45QSO73OB
  • StreptomycinPTNCI
DEFINITION
  • An aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, streptomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI
code
  • C61952
is Has_Free_Acid_Or_Base_Form of
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