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AttributesValues
rdf:type
rdfs:label
  • Pegvisomant
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pegvisomant
UMLS_CUI
  • C1174777
CAS_Registry
  • 218620-50-9
FDA_UNII_Code
  • N824AOU5XV
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 655949
PDQ_Closed_Trial_Search_ID
  • 655949
Legacy_Concept_Name
  • Pegvisomant
FULL_SYN
  • PegvisomantPTNCI
  • PegvisomantPTDCP50484
  • Somatotropin (18-Aspartic Acid, 21-Asparagine, 120-Lysine, 167-Asparagine, 168-Alanine, 171-Serine, 172-Arginine, 174-Serine, 179-Threonine) (Human), PegylatedSYNCI
  • TrovertBRNCI
  • SomavertBRNCI
  • PEGVISOMANTPTFDAN824AOU5XV
DEFINITION
  • A pegylated, recombinant, human growth hormone (GH) structural analog with GH receptor antagonist activity. As a GH analog, the structure of pegvisomant is similar to that of native GH with the exception of 9 amino acid substitutions. Pegvisomant selectively binds to GH receptors on cell surfaces, interfering with endogenous GH receptor binding and so GH signal transduction. Inhibition of GH signal transduction results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and other GH-responsive serum proteins, including IGF binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS), and may inhibit the growth of cancers in which IGF-1 is upregulated.NCI
code
  • C61881
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