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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Inamrinone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Inamrinone
UMLS_CUI
  • C0002697
CAS_Registry
  • 60719-84-8
FDA_UNII_Code
  • JUT23379TN
Contributing_Source
  • FDA
Chemical_Formula
  • C10H9N3O
Legacy_Concept_Name
  • Inamrinone
FULL_SYN
  • INAMRINONEPTFDAJUT23379TN
  • AmrinoneSYNCI
  • InamrinonePTNCI
DEFINITION
  • A synthetic bipyridine phosphodiesterase inhibitor with inotropic and vasodilator properties. Inamrinone inhibits type III phosphodiesterase, which is abundant in cardiac and vascular tissues, thereby preventing the degradation of cyclic adenosine monophosphate (cAMP) and increasing intracellular concentrations of this secondary messenger. Elevated levels of cAMP increase the contractile force of the cardiac muscle and produce positive inotropic effects. Although the mechanism of action is not fully understood, inamrinone causes smooth muscle relaxation, resulting in peripheral vasodilation (reduced afterload) and a decreased pulmonary vascular resistance (reduced preload).NCI
code
  • C61789
is Has_Free_Acid_Or_Base_Form of
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