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AttributesValues
rdf:type
rdfs:label
  • Doxazosin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Doxazosin
UMLS_CUI
  • C0114873
CAS_Registry
  • 74191-85-8
FDA_UNII_Code
  • NW1291F1W8
Contributing_Source
  • FDA
Chemical_Formula
  • C23H25N5O5
Legacy_Concept_Name
  • Doxazosin
CHEBI_ID
  • CHEBI:4708
FULL_SYN
  • DoxazosinPTDCP31754
  • DOXAZOSINPTFDANW1291F1W8
  • DoxazosinPTNCI
DEFINITION
  • A quinazoline with antihypertensive and antineoplastic properties. Doxazosin is an alpha-adrenergic antagonist that selectively inhibits alpha-1 adrenergic receptors. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia. Furthermore, doxazosin induces apoptosis in prostate cancer cells mediated through inhibition of protein kinase B (PKB)/Akt-signaling death receptor regulatory pathway.NCI
code
  • C61737
is Has_Free_Acid_Or_Base_Form of
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