About: Disopyramide     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Disopyramide
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Disopyramide
UMLS_CUI
  • C0012702
CAS_Registry
  • 3737-09-5
FDA_UNII_Code
  • GFO928U8MQ
Contributing_Source
  • FDA
Chemical_Formula
  • C21H29N3O
Legacy_Concept_Name
  • Disopyramide
CHEBI_ID
  • CHEBI:4657
FULL_SYN
  • DISOPYRAMIDEPTFDAGFO928U8MQ
  • DisopyramidePTNCI
DEFINITION
  • A class IA anti-arrhythmic agent with cardiac depressant property. Disopyramide blocks the fast sodium channel in normal cardiac cell membranes within atrial and ventricular tissues. This slows the rate and amplitude of phase 0 depolarization and thus prolongs the duration of the action potential, thereby reducing cell excitability and conduction velocity. Further, disopyramide directly decreases the rate of diastolic (phase 4) depolarization in cells with normal or augmented automaticity. Disopyramide also blocks potassium channel and results in prolonged QT interval, thus increases the effective refractory period. This agent also possesses anticholinergic property.NCI
code
  • C61730
is Has_Free_Acid_Or_Base_Form of
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