About: Lomustine

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Attributes	Values
rdf:type	Class
rdfs:label	Lomustine
rdfs:subClassOf	Nitrosourea Compounds
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Lomustine
NSC_Code	79037
UMLS_CUI	C0699181
CAS_Registry	13010-47-4
Accepted_Therapeutic_Use_For	Brain tumors; Hodgkins disease
In_Clinical_Trial_For	AIDS-related non-Hodgkins lymphoma; Brain tumor; Central nervous system lymphoma; Malignant glioma; Medulloblastoma
FDA_UNII_Code	7BRF0Z81KG
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43065
PDQ_Closed_Trial_Search_ID	43065
Chemical_Formula	C9H16ClN3O2
Legacy_Concept_Name	Lomustine
FULL_SYN	LomustinumSYNCI CCNUSYDTPNSC0079037 ChloroethylcyclohexylnitrosoureaSYNCI LomeblastinFBNCI ChloroethylcyclohexylnitrosoureaSYDTPNSC0079037 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoureaSNNCI CeeNUSYDTPNSC0079037 Chloroethylcyclo- hexylnitrosoureaSNNCI N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosoureaSNNCI CecenuSYDTPNSC0079037 CCNUABNCI CeeNUBRNCI PravaFBNCI 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosoureaSYDTPNSC0079037 CecenuFBNCI LOMUSTINEPTFDA7BRF0Z81KG RB-1509CNNCI BelustineSYDTPNSC0079037 N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosoureaSYDTPNSC0079037 CitostalFBNCI BelustinFBNCI LucostinFBNCI WR-139017CNNCI BelustineFBNCI LucostineFBNCI 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-SYDTPNSC0079037 LomustinePTNCI lomustinePTNCI-GLOSSCDR0000046017
DEFINITION	A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04)NCI
code	C617
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