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AttributesValues
rdf:type
rdfs:label
  • Cefoxitin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cefoxitin
UMLS_CUI
  • C0007557
CAS_Registry
  • 35607-66-0
FDA_UNII_Code
  • 6OEV9DX57Y
Contributing_Source
  • FDA
Chemical_Formula
  • C16H17N3O7S2
Legacy_Concept_Name
  • Cefoxitin
CHEBI_ID
  • CHEBI:209807
FULL_SYN
  • CEFOXITINPTFDA6OEV9DX57Y
  • CefoxitinPTNCI
DEFINITION
  • A semisynthetic, broad-spectrum, second-generation cephalosporin with antibacterial activity. Cefoxitin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C61665
is Has_Free_Acid_Or_Base_Form of
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