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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amlodipine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amlodipine
UMLS_CUI
  • C0051696
CAS_Registry
  • 88150-42-9
FDA_UNII_Code
  • 1J444QC288
Contributing_Source
  • FDA
Chemical_Formula
  • C20H25ClN2O5
Legacy_Concept_Name
  • Amlodipine
CHEBI_ID
  • CHEBI:2668
FULL_SYN
  • AmlodipinePTDCP32073
  • AMLODIPINEPTFDA1J444QC288
  • AmlodipinePTNCI
DEFINITION
  • A synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug response (MDR) activity through inhibition of the p-glycoprotein efflux pump.NCI
code
  • C61635
is Has_Free_Acid_Or_Base_Form of
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