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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amantadine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amantadine
UMLS_CUI
  • C0002403
CAS_Registry
  • 768-94-5
FDA_UNII_Code
  • BF4C9Z1J53
Contributing_Source
  • FDA
Chemical_Formula
  • C10H17N
Legacy_Concept_Name
  • Amantadine
CHEBI_ID
  • CHEBI:2618
FULL_SYN
  • AMANTADINEPTFDABF4C9Z1J53
  • AmantadinePTNCI
DEFINITION
  • A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.NCI
code
  • C61632
is Has_Free_Acid_Or_Base_Form of
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