About: Amikacin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Amikacin
rdfs:subClassOf	AMINOGLYCOSIDES
Has_Salt_Form	Amikacin Sulfate
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Carbohydrate
Preferred_Name	Amikacin
UMLS_CUI	C0002499
CAS_Registry	37517-28-5
FDA_UNII_Code	84319SGC3C
Contributing_Source	FDA
ALT_DEFINITION	An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.NCI-GLOSS
Chemical_Formula	C22H43N5O13
Legacy_Concept_Name	Amikacin_Base
CHEBI_ID	CHEBI:2637
FULL_SYN	AMIKACINPTFDA84319SGC3C AmikacinSYDTPNSC0177001 amikacinPTNCI-GLOSSCDR0000045174 AmikacinPTNCI
DEFINITION	A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and , misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.NCI
code	C61615
is Has_Free_Acid_Or_Base_Form of	Amikacin Sulfate

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