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AttributesValues
rdf:type
rdfs:label
  • Pemetrexed
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pemetrexed
NSC_Code
  • 698037
UMLS_CUI
  • C0210657
CAS_Registry
  • 137281-23-3
FDA_UNII_Code
  • 04Q9AIZ7NO
Contributing_Source
  • FDA
Chemical_Formula
  • C20H21N5O6
Legacy_Concept_Name
  • Pemetrexed_Base
CHEBI_ID
  • CHEBI:63616
FULL_SYN
  • Multitargeted AntifolateSYNCI
  • L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)SNNCI
  • MTAABNCI
  • PEMETREXEDPTFDA04Q9AIZ7NO
  • PemetrexedPTNCI
DEFINITION
  • A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.NCI
code
  • C61614
is Has_Free_Acid_Or_Base_Form of
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