About: Alpha-Lipoic Acid     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Alpha-Lipoic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Alpha-Lipoic Acid
UMLS_CUI
  • C0023791
CAS_Registry
  • 1077-28-7
In_Clinical_Trial_For
  • Prevention of Chemotherapy-Induced Neuropathy
FDA_UNII_Code
  • 73Y7P0K73Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha-lipoic acid is made by the body and can be found in foods such as organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran. It can also be made in the laboratory. Alpha-lipoic acid is a type of antioxidant and chemoprotective agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 440740
PDQ_Closed_Trial_Search_ID
  • 440740
Chemical_Formula
  • C8H14O2S2
Legacy_Concept_Name
  • Alpha-Lipoic_Acid
CHEBI_ID
  • CHEBI:16494
FULL_SYN
  • alpha-lipoic acidPTNCI-GLOSSCDR0000443026
  • Lipoic AcidSYNCI
  • Thioctic AcidSYNCI
  • 5-(1,2-Dithiolan-3-yl)pentanoic AcidSNNCI
  • 6,8-Thioctic AcidSNNCI
  • Thioctic AcidPTDCP03352
  • Alpha-Lipoic AcidPTNCI
  • .ALPHA.-LIPOIC ACIDPTFDA73Y7P0K73Y
  • ThioctateSYNCI
DEFINITION
  • A naturally occurring micronutrient, synthesized in small amounts by plants and animals (including humans), with antioxidant and potential chemopreventive activities. Alpha-lipoic acid acts as a free radical scavenger and assists in repairing oxidative damage and regenerates endogenous antioxidants, including vitamins C and E and glutathione. This agent also promotes glutathione synthesis. In addition, alpha-lipoic acid exerts metal chelating capacities and functions as a cofactor in various mitochondrial enzyme complexes involved in the decarboxylation of alpha-keto acids.NCI
code
  • C61595
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