About: Bendamustine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Bendamustine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Bendamustine Hydrochloride
NSC_Code
  • 138783
UMLS_CUI
  • C1529660
CAS_Registry
  • 3543-75-7
Accepted_Therapeutic_Use_For
  • chronic lymphocytic leukemia
FDA_UNII_Code
  • 981Y8SX18M
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat chronic lymphocytic leukemia (CLL). It is also used to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs.It is being studied in the treatment of other types of cancer. Bendamustine hydrochloride may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 350251
PDQ_Closed_Trial_Search_ID
  • 350251
Chemical_Formula
  • C16H21Cl2N3O2.ClH
Legacy_Concept_Name
  • Bendamustine_Hydrochloride
FULL_SYN
  • Cytostasan HydrochlorideSYNCI
  • Bendamustin HydrochlorideSYNCI
  • Bendamustine HydrochloridePTNCI
  • bendamustine hydrochloridePTNCI-GLOSSCDR0000386197
  • 2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochlorideSNNCI
  • TreandaPTNCI-GLOSSCDR0000594104
  • TreandaBRNCI
  • BENDAMUSTINE HYDROCHLORIDEPTFDA981Y8SX18M
  • SyB L-0501CNNCI
  • RibomustinFBNCI
DEFINITION
  • The hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators.NCI
code
  • C61565
is Has_Salt_Form of
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