About: Recombinant Human Hyaluronidase     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Human Hyaluronidase
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Enzyme
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Human Hyaluronidase
UMLS_CUI
  • C1720035
CAS_Registry
  • 757971-58-7
FDA_UNII_Code
  • 743QUY4VD8
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 486735
PDQ_Closed_Trial_Search_ID
  • 486735
Legacy_Concept_Name
  • Recombinant_Human_Hyaluronidase
FULL_SYN
  • HYALURONIDASE (HUMAN RECOMBINANT)PTFDA743QUY4VD8
  • rHuPH20ABNCI
  • HylenexBRNCI
  • Recombinant Human HyaluronidasePTNCI
  • Hyaluronidase Recombinant HumanSYNCI
  • ChemophaseBRNCI
DEFINITION
  • A human recombinant form of the naturally occurring human enzyme hyaluronidase with potential chemoadjuvant activity. Upon local administration, recombinant human hyaluronidase hydrolyzes hyaluronic acid, a glucosaminoglycan responsible for the viscosity of the interstitial barrier. The digestion of hyaluronic acid lowers the viscosity in the interstitial space, thereby increasing permeability and facilitating local penetration of chemotherapeutic agents into cancer cells.NCI
code
  • C61504
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