About: TLR7 Agonist 852A     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • TLR7 Agonist 852A
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • TLR7 Agonist 852A
UMLS_CUI
  • C1541384
ALT_DEFINITION
  • A substance being studied in the treatment of certain adult and childhood blood cancers and other types of cancer. 852A may help the patient's immune system block tumor growth. It is a type of immune system modulator.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 396824
PDQ_Closed_Trial_Search_ID
  • 396824
Legacy_Concept_Name
  • _852A
FULL_SYN
  • 852APTNCI-GLOSSCDR0000488411
  • 852ACNNCI
  • TLR7 Agonist 852APTNCI
DEFINITION
  • A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7, thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent signaling pathway. Activation of pDC results in secretion of interferon alpha, the production of proimflammatory cytokines, the upregulation of co-stimulatory molecules, and enhanced T and B-cell stimulatory responses.NCI
code
  • C61104
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