About: Sepantronium Bromide     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sepantronium Bromide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Sepantronium Bromide
UMLS_CUI
  • C2002939
CAS_Registry
  • 781661-94-7
FDA_UNII_Code
  • 7H5Q4J1CM5
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 476771
PDQ_Closed_Trial_Search_ID
  • 476771
Chemical_Formula
  • C20H19N4O3.Br
Legacy_Concept_Name
  • YM155
FULL_SYN
  • SEPANTRONIUM BROMIDEPTFDA7H5Q4J1CM5
  • Survivin Inhibitor YM155SYNCI
  • YM-155CNNCI
  • 1H-Naphth(2,3-d)imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazinylmethyl)-, BromideSNNCI
  • Sepantronium BromidePTNCI
DEFINITION
  • A small-molecule proapoptotic agent with potential antineoplastic activity. Sepantronium bromide selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is expressed during embryonal development and is absent in most normal, terminally differentiated tissues; upregulated in a variety of human cancers, its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy.NCI
code
  • C61091
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