About: Paclitaxel Vitamin E-Based Emulsion

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Attributes	Values
rdf:type	Class
rdfs:label	Paclitaxel Vitamin E-Based Emulsion
rdfs:subClassOf	Paclitaxel Preparation
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Paclitaxel Vitamin E-Based Emulsion
UMLS_CUI	C1541793
PDQ_Open_Trial_Search_ID	474798
PDQ_Closed_Trial_Search_ID	474798
Legacy_Concept_Name	Tocosol_Paclitaxel
FULL_SYN	Paclitaxel Vitamin E-Based EmulsionPTNCI PIEABNCI S-8184CNNCI TocosolBRNCI Paclitaxel Injectable EmulsionSYNCI
DEFINITION	A cremophor-free, P-glycoprotein-inhibiting, vitamin E-based emulsion particle formulation of paclitaxel with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (Bcl-2). The vitamin-E based emulsion allows bolus infusion without steroid premedication and may diminish hypersensitivity reactions. The tumor tissue may be passively targeted due to preferential deposition of emulsion particles while an emulsion formulation component inhibits the P-glycoprotein drug efflux pump.NCI
code	C61079

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