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AttributesValues
rdf:type
rdfs:label
  • Bosutinib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Bosutinib
UMLS_CUI
  • C1831731
CAS_Registry
  • 380843-75-4
In_Clinical_Trial_For
  • Philadelphia chromosome positive leukemias; breast cancer; advanced malignant solid tumors
FDA_UNII_Code
  • 5018V4AEZ0
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 467222
PDQ_Closed_Trial_Search_ID
  • 467222
Chemical_Formula
  • C26H29Cl2N5O3
Legacy_Concept_Name
  • Bosutinib
CHEBI_ID
  • CHEBI:39112
FULL_SYN
  • 4-Anilino-3-quinolinecarbonitrileSNNCI
  • 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrileSNNCI
  • BOSUTINIBPTFDA5018V4AEZ0
  • SKI 606CNNCI
  • SKI-606CNNCI
  • SKI-606PTDCP32145
  • BosulifBRNCI
  • 4-Anilinobenzo(g)quinoline-3-carbonitrileSNNCI
  • BosutinibPTNCI
DEFINITION
  • A synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype.NCI
code
  • C60809
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