About: CpG-28 Oligodeoxynucleotide     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CpG-28 Oligodeoxynucleotide
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • CpG-28 Oligodeoxynucleotide
OLD_PARENT
  • Immunostimulant
  • Phosphorothioate_Oligonucleotide
OLD_KIND
  • Chemicals_and_Drugs_Kind
In_Clinical_Trial_For
  • Malignant Glioblastoma
Concept_Status
  • Retired_Concept
FULL_SYN
  • CpG-28 OligodeoxynucleotidePTNCI
  • CpG-28CNNCI
  • CpG ODNSYNCI
DEFINITION
  • A synthetic oligodeoxynucleotide containing multiple repeats of unmethylated CpG motifs (CpG ODN) with immunostimulatory activity. Upon entering the cell via endocytosis, CpG-28 activates numerous signaling transduction pathways resulting in the release of multiple cytokines. CpG-28 has immunomodulatory properties with direct activation of B-lymphocytes, dendritic and NK cells resulting in the stimulation of innate immunity and antibody-dependant cell cytotoxicity (ADCC). Additionally, this agent indirectly modulates T-cell responses though the release of cytokines (IL-12 and IFN gamma) to induce a preferential shift to the Th1 (helper) phenotype resulting in enhanced CD8+ cellular cytotoxicity.NCI
DesignNote
  • See 'CpG oligodeoxynucleotide'
code
  • C60806
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