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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Daniplestim
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Daniplestim
UMLS_CUI
  • C0297038
CAS_Registry
  • 161753-30-6
FDA_UNII_Code
  • 491EKS8W4C
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Daniplestim
FULL_SYN
  • DaniplestimPTNCI
  • SC-55494CNNCI
  • DANIPLESTIMPTFDA491EKS8W4C
  • SynthokineBRNCI
DEFINITION
  • A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic potency. Daniplestim exhibits 10- to 20-fold greater biological activity than recombinant human IL-3 in human hematopoietic cell proliferation and marrow colony-forming-unit assays. In contrast, this agent shows no significant increase in pro-inflammatory activity relative to native IL-3. The enhanced hematopoietic activity of daniplestim correlates with a 60-fold increase in IL-3 alpha-subunit binding affinity and 20-fold greater affinity for binding to alpha/beta receptor complexes on intact cells relative to recombinant IL-3.NCI
code
  • C60775
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