About: Indium In 111 CHX-A DTPA Trastuzumab     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Indium In 111 CHX-A DTPA Trastuzumab
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Indium In 111 CHX-A DTPA Trastuzumab
NSC_Code
  • 740377
NCI_META_CUI
  • CL360663
ALT_DEFINITION
  • A substance being studied in the imaging of breast cancer and some other types of cancer. It is made by attaching a radioactive substance called indium 111 to the monoclonal antibody trastuzumab (Herceptin). Trastuzumab binds to the human growth factor receptor 2 (HER2/neu) on some breast cancer cells and on several other types of cancer cells. Indium In 111 CHX-A DTPA trastuzumab is a type of radioimmunoconjugate.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 543723
PDQ_Closed_Trial_Search_ID
  • 543723
Legacy_Concept_Name
  • Indium-CHX-A_DTPA-Trastuzumab
FULL_SYN
  • Indium In 111 CHX-A DTPA TrastuzumabPTNCI
  • 111In-CHX-A"-DTPA-TrastuzumabSYNCI
  • indium In 111 CHX-A DTPA trastuzumabPTNCI-GLOSSCDR0000559139
DEFINITION
  • An indium In 111-labeled trastuzumab with potential use as an imaging agent. Indium In 111 CHX-A DTPA trastuzumab is chemically conjugated via a bifunctional metal chelator molecule, 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A DTPA), a backbone-substituted derivative of DTPA. This agent may allow radioimmunolocalization of HER2-positive cells. Trastuzumab, a recombinant humanized monoclonal antibody that selectively binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2), may elicit an antibody-dependent cellular cytotoxicity (ADCC) against tumor cells that overexpress HER2.NCI
code
  • C60766
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 123 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software