| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:label
| |
| rdfs:subClassOf
| |
| Has_Free_Acid_Or_Base_Form
| |
| Concept_In_Subset
| |
| Semantic_Type
| - Organic Chemical
- Pharmacologic Substance
|
| Preferred_Name
| |
| NSC_Code
| |
| UMLS_CUI
| |
| CAS_Registry
| |
| Accepted_Therapeutic_Use_For
| - Megaloblastic anemia due to folate deficiency; Enhanced fluorouracil inhibition of thymidylate synthase; Reverse dihydrofolate reductase inhibition by methotrexate; Folic acid antagonist overdose; Nitrous Oxide toxicity
|
| In_Clinical_Trial_For
| - Metastatic osteosarcoma; Pancreatic cancer; Rectal cancer; Small Intestine adenocarcinoma; Solid tumor; Toxoplasmosis; Urethral cancer
- Bladder cancer; Childhood rhabdoid tumor of the central nervous system; Colon cancer; Esophageal cancer; Gastric cancer; Glioblastoma multiforme; Leukemias; Lymphomas;
|
| FDA_UNII_Code
| |
| Contributing_Source
| |
| ALT_DEFINITION
| - A drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate. Leucovorin calcium is used to treat some types of anemia and is also used with fluorouracil to treat colorectal cancer. It is also being studied in the treatment of other types of cancer and other conditions. Leucovorin calcium is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent.NCI-GLOSS
|
| PDQ_Open_Trial_Search_ID
| |
| PDQ_Closed_Trial_Search_ID
| |
| Legacy_Concept_Name
| |
| FULL_SYN
| - WellcovorinBRNCI
- leucovorinPTNCI-GLOSSCDR0000045750
- citrovorum factorPTNCI-GLOSSCDR0000613203
- WellcovorinPTNCI-GLOSSCDR0000613207
- leucovorin calciumPTNCI-GLOSSCDR0000613205
- 5-Formyl TetrahydrofolateSNNCI
- folinic acidPTNCI-GLOSSCDR0000613202
- Calcium N-(p-((((6RS)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)SNNCI
- ImoFBNCI
- 5-Formyl-5,6,7,8-tetrahydrofolic AcidSNNCI
- Calcium FolinateSYNCI
- Folinate CalciumSYNCI
- FolixFBNCI
- Folinic Acid Calcium Salt PentahydrateSYNCI
- Citrovorum FactorSYNCI
- EcofolFBNCI
- CitrecFBNCI
- EmovisFBNCI
- Factor, CitrovorumSYNCI
- Calcium LeucovorinSYNCI
- Leucovorin CalciumPTNCI
- CalinatFBNCI
- DivicalFBNCI
- FolinacFBNCI
- FolidanFBNCI
- FolibenFBNCI
- FolidarFBNCI
- FolarenFBNCI
- DalisolFBNCI
- FolaxinFBNCI
- LEUCOVORIN CALCIUMPTFDARPR1R4C0P4
- 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic AcidSNNCI
- AdineparFBNCI
- CalfolexFBNCI
- LeucosarFBNCI
- FolinvitFBNCI
- FoliplusFBNCI
- DisintoxFBNCI
- N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic Acid, Calcium Salt (1:1)SNNCI
- FOLI-cellFBNCI
- Cromatonbic FolinicoFBNCI
- CehafolinFBNCI
- FolinoralFBNCI
- CitofolinFBNCI
- TonofolinFBNCI
- N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic AcidSNNCI
- Calcium (6S)-FolinateSYNCI
- Flynoken AFBNCI
- CalcifolinFBNCI
- LederfolatFBNCI
- LederfolinFBNCI
- RescufolinFBNCI
- RescuvolinFBNCI
|
| DEFINITION
| - An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. (NCI04)NCI
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