About: Ketoconazole

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Attributes	Values
rdf:type	Class
rdfs:label	Ketoconazole
rdfs:subClassOf	Non-Steroidal Aromatase Inhibitor Anti-infective Agent nodeID://b685480
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Ketoconazole
NSC_Code	317629
UMLS_CUI	C0022625
CAS_Registry	65277-42-1
Accepted_Therapeutic_Use_For	Seborrheic Dermatitis; Prostate cancer
In_Clinical_Trial_For	Prostatic neoplasms; Unspecified solid tumor
FDA_UNII_Code	R9400W927I
Contributing_Source	FDA
ALT_DEFINITION	A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39488
PDQ_Closed_Trial_Search_ID	39488
Chemical_Formula	C26H28Cl2N4O4
Legacy_Concept_Name	Ketoconazole
CHEBI_ID	CHEBI:47519
FULL_SYN	KETOCONAZOLEPTFDAR9400W927I Orifungal MFBNCI KetoconazoleSYDTPNSC0317629 KetoconazolePTNCI ketoconazolePTNCI-GLOSSCDR0000045222 KetoconazolePTDCP20436 Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazineSNNCI R-41400CNNCI XolegelBRNCI NizoralBRNCI KetodermFBNCI FungoralFBNCI PanfungolFBNCI KetoisdinFBNCI FungarestFBNCI
DEFINITION	A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)NCI
code	C605
is someValuesFrom of	nodeID://b644832 nodeID://b657356 nodeID://b663714 nodeID://b666919 nodeID://b666924 nodeID://b666930 nodeID://b667173 nodeID://b667370 nodeID://b667587 nodeID://b671160 nodeID://b674198 nodeID://b674200 nodeID://b680750 nodeID://b685482 nodeID://b685484

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