About: Recombinant Interleukin-6

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Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Interleukin-6
equivalentClass	nodeID://b640576
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Recombinant Interleukin-6
UMLS_CUI	C1527132
ALT_DEFINITION	One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-6 is made mainly by some T lymphocytes. It causes B lymphocytes to make more antibodies and also causes fever by affecting areas of the brain that control body temperature. Interleukin-6 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-6 is a type of cytokine.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41474
PDQ_Closed_Trial_Search_ID	41474
Legacy_Concept_Name	Therapeutic_Interleukin-6
FULL_SYN	Hybridoma Growth FactorSYNCI IL-6PTNCI-GLOSSCDR0000044421 HSFABNCI Plasmacytoma Growth FactorSYNCI IL-6ABNCI HPGFABNCI B-Cell Stimulatory Factor-2SYNCI Hepatocyte Stimulating FactorSYNCI Myeloid Differentiation Inducing ProteinSYNCI B Cell Differentiation Factor 2SYNCI IFN Beta 2SYNCI Recombinant Interleukin-6PTNCI Interleukin-6PTNCI-GLOSSCDR0000044045 SigosixBRNCI
DEFINITION	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, antiinflammatory, proproliferative and proangiogenic activities. IL-6 binds to its receptor (IL-6R), activating a receptor-CD130 receptor complex; the CD130 portion of the complex is a signal transduction protein that activates JAK kinases and Ras-mediated signaling pathways, which in turn activate downstream signaling pathways, resulting in the activation of various transcription factors (STAT, ELK-1, NF-IL-6, etc.) and gene transcription. The physiological effects of IL-6 are complex and varied and include hematopoietic, pyrogenic and thermogenic, proinflammatory, antiinflammatory, proproliferative (anti-apoptotic), and angiogenic effects.NCI
code	C591
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