About: Recombinant Interleukin-1-beta

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Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Interleukin-1-beta
rdfs:subClassOf	Recombinant Interleukin-1
Is_Related_To_Endogenous_Product	Interleukin-1beta
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	Recombinant Interleukin-1-beta
UMLS_CUI	C1522432
PDQ_Open_Trial_Search_ID	40793
PDQ_Closed_Trial_Search_ID	40793
Legacy_Concept_Name	Recombinant_Interleukin-1-beta
FULL_SYN	IL-1-bABNCI interleukin-1-betaSYNCI Recombinant Interleukin-1-betaPTNCI
DEFINITION	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes and activated macrophages, endogenous mature IL-1 is generated through proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent promotes angiogenesis, fibroblast proliferation, and neutrophil chemotaxis; it also regulates the functions of lymphocytes and epithelial cells and is involved in the 'acute phase response' to infection. (NCI04)NCI
code	C585
is someValuesFrom of	nodeID://b656848 nodeID://b657068 nodeID://b673572 nodeID://b673921 nodeID://b683232 nodeID://b683461

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