About: Phase II Enzymes Inducer     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Phase II Enzymes Inducer
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Phase II Enzymes Inducer
UMLS_CUI
  • C1883668
Legacy_Concept_Name
  • Phase_II_Enzymes_Inducer
FULL_SYN
  • Phase II Enzymes InducerPTNCI
DEFINITION
  • Any natural or synthetic substance that enhances the activity of any phase II metabolic enzymes. Phase II detoxification enzymes, such as glutathione-S-transferase (GST), glucuronyl transferase, acyl transferase, or sulfotransferase, catalyze conjugation reactions of xenobiotics or metabolites formed in phase I reactions. Conjugation reactions greatly enhance polarity of xenobiotics or their metabolites, thereby facilitate their elimination from the body. Phase II conjugation reactions include glucuronidation, methylation, acetylation, and glutathione, sulfate and amino acid conjugation.NCI
code
  • C54630
is rdfs:subClassOf of
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