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AttributesValues
rdf:type
rdfs:label
  • Pibenzimol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pibenzimol
NSC_Code
  • 322921
UMLS_CUI
  • C0019832
CAS_Registry
  • 23491-45-4
FDA_UNII_Code
  • LHQ7J5KV9B
Contributing_Source
  • FDA
ALT_DEFINITION
  • A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39193
PDQ_Closed_Trial_Search_ID
  • 39193
Chemical_Formula
  • C25H24N6O
Legacy_Concept_Name
  • Pibenzimol
CHEBI_ID
  • CHEBI:52082
FULL_SYN
  • Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, TrihydrochlorideSNNCI
  • Hoechst 33258CNNCI
  • Phenol, p-[5-[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]-2- benzimidazolyl]-, TrihydrochlorideSNNCI
  • Pibenzimol HydrochlorideSYNCI
  • BisbenzimidazoleSYNCI
  • Hoechst Dye 33258SYNCI
  • Hoe 33258SYDTPNSC0322921
  • Hoechst dye 33258SYDTPNSC0322921
  • PIBENZIMOLPTFDALHQ7J5KV9B
  • HOE 33258CNNCI
  • PibenzimolPTNCI
DEFINITION
  • A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04)NCI
code
  • C546
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