About: Altretamine

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Attributes	Values
rdf:type	Class
rdfs:label	Altretamine
rdfs:subClassOf	Aziridines
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Altretamine
NSC_Code	13875
UMLS_CUI	C0019453
CAS_Registry	645-05-6
FDA_UNII_Code	Q8BIH59O7H
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39475
PDQ_Closed_Trial_Search_ID	39475
Chemical_Formula	C9H18N6
Legacy_Concept_Name	Altretamine
CHEBI_ID	CHEBI:24564
FULL_SYN	HexamethylmelamineSYDTPNSC0013875 AltretamineSYDTPNSC0013875 N,n,n',N"N"-hexamethyl-1,3,5,-triazine-2,4,6,-triamineSNNCI AltretaminePTNCI HemelSYDTPNSC0013875 altretaminePTNCI-GLOSSCDR0000045215 N,N,N',N',N",N"-hexamethyl-1,3,5-triazine-2,4,6-triamineSNNCI 2,4,6-tris(dimethylamino)-s-triazineSNNCI HMMABNCI HXMABNCI 2,4,6-Tris(dimethylamino)-s-triazineSYDTPNSC0013875 HemelSYNCI ENT 50852SYDTPNSC0013875 HexastatSYDTPNSC0013875 RB-1515CNNCI s-Triazine, 2,4,6-tris(dimethylamino)-SYDTPNSC0013875 HexamethylmelamineBRNCI HexalenBRNCI WR-95704CNNCI HexastatFBNCI ENT-50852CNNCI ALTRETAMINEPTFDAQ8BIH59O7H HexinawasFBNCI HexaloidsSYNCI
DEFINITION	A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)NCI
code	C544
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