About: MANF wt Allele     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MANF wt Allele
rdfs:subClassOf
OMIM_Number
  • 601916
GenBank_Accession_Number
  • M83751
Semantic_Type
  • Gene or Genome
Preferred_Name
  • MANF wt Allele
UMLS_CUI
  • C1705841
EntrezGene_ID
  • 7873
Legacy_Concept_Name
  • ARMET_wt_Allele
HGNC_ID
  • HGNC:15461
FULL_SYN
  • Mesencephalic Astrocyte-Derived Neurotrophic Factor wt AlleleSYNCI
  • MANF wt AllelePTNCI
  • ARPSYNCI
  • ARMETSYNCI
  • Arginine-Rich Mutated In Early Stage Tumors GeneSYNCI
  • MGC142150SYNCI
  • MGC142148SYNCI
DEFINITION
  • Human MANF wild-type allele is located in the vicinity of 3p21.1 and is approximately 4 kb in length. This allele, which encodes mesencephalic astrocyte-derived neurotrophic factor protein, plays a role in both the modulation of GABA neurotransmission and the mediation of dopaminergic neuron survival.NCI
DesignNote
  • The product of the MANF gene was originally thought to have an arginine-rich sequence in the amino terminal region, however; this genetic information is in the 5'-untranslated region of the mRNA. The mutation that is involved in tumor formation occurs in the initiation codon of the gene (previously numbered as codon 50) and results from either deletion of the codon or a point mutation (AUG to AGG). (Entrez Gene and SwissProt)
code
  • C54330
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